HOPA Research Grantees

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2022 HOPA Research Grant Awardees

Kirollos Hanna, PharmD Pharmacist

Intervention in Oral Chemotherapy: Minimizing Toxicity with Telemonitoring and the PRO-CTCAET

Grant Amount: $34,500

As oral chemotherapy is being utilized more commonly in many various cancer treatments and has risks for increased adverse events and nonadherence; this study looked to determine if integrating a pharmacist with patient reported outcomes (PRO) of adverse events and new availability of telemedicine visits could improve potential toxicity, provide more real-time monitoring, and benefit the health system. The study design included comparing patients with normal standard of care monitoring and patients providing toxicity information via PRO-CTCAE every 7 days or with new toxicity which prompted a pharmacist led review and/or intervention. They were able to conclude this new process has the potential to improve outcomes for patients on oral chemotherapy agents and benefit the health system.

Narendranath Epperla and Jordan Lundberg, PharmD

Effect of pharmacogenomics on clearance of high-dose methotrexate in patients with diffuse large B-cell lymphoma

Grant Amount: $58,000

Drs. Epperla and Lundberg are performing a prospective trial to identify single nucleotide polymorphisms (SNPs) in genes associated with delayed methotrexate clearance and increased toxicity in adult DLBCL patients receiving high dose methotrexate. Identifying patients most likely to experience toxicity could improve care by decreasing nephrotoxicity, length of admission, and glucaparidase administration. This research could lead to a cost-effective pharmacogenomics test to identify patients at high risk for methotrexate toxicity and optimize their management.

2021 HOPA Research Grant Awardees

Angela Stover, PharmD

Budgeting and piloting the patient centered pharmacy pathway for oral chemotherapy

Grant Amount: $44,920

Adverse effects from oral chemotherapy remain a significant barrier to adherence which can lead to poorer outcomes. Pharmacists are uniquely positioned to address barriers to adherence. Dr. Stover’s pilot study seeks to incorporate patient reported outcome measures into a patient-centered process to facilitate pharmacist intervention. This pilot study will assess whether this intervention improves patient reported adverse effects and efficacy outcomes.

Alexandre Chan, PharmD

PRO-Driven pharmacy education in ethnic minority patients receiving anti-cancer therapies

Grant Amount: $38,116

Cancer care disparities in ethnic minorities result in poor patient outcomes. Training pharmacists to recognize early issues of cancer care barriers earlier may improve cancer care in ethnic minorities. To address the problem, Dr. Chan’s PRIORITIES study seeks to utilize an established framework and incorporate pharmacist education into ethnic minorities cancer care. This study will assess the satisfaction and acceptance of pharmacist intervention and education.

2020 HOPA Research Grant Awardees

Benjamin Andrick, PharmD

Machine Learning Approach to Venous Thromboembolism Prediction in Newly Diagnosed Patients with Cancer Receiving Chemotherapy

Grant Amount: $92,000

The objective of Dr. Andrick’s study is to determine if a machine learning model can outperform the Khorana Score in predicting VTE in cancer patients. Several different algorithms will be compared against the Khorana Score. Additionally, known genetic risk factors will be incorporated to determine if these can increase predictive capabilities of the machine models. If successful, this study can highlight alternative strategies to improve the prediction of cancer patients’ risk of VTE.

Alison Palumbo, PharmD

Remote Patient Reported Quality of Life Outcomes in Patients on Oral Anti-Cancer Therapy

Grant Amount: $8,000

Quality of life impact for patients on oral chemotherapy has not been well defined. Patient reported outcomes (PROs) provide many benefits including improved outcomes, convenience, and opportunity for intervention to improve quality of life and reduce toxicity. The goal of this study is to determine the feasibility and utility of using electronic patient reported outcomes for quality of life.